進行胃癌症例におけるａｐｏｐｔｏｓｉｓと増殖活性の検討

• 稲田 高男

  栃木県立がんセンター外科

• 尾形 佳郎

  栃木県立がんセンター外科

• 市川 明

  栃木県立がんセンター研究検査部

• 五十嵐 誠治

  栃木県立がんセンター研究検査部

書誌事項

タイトル別名

• Apoptosis and Proliferative Activity of Advanced Gastric Cancer.

抄録

We investigated the significance of apoptosis in advanced gastric cancer and its relation to the expression of bcl-2 oncoprotein, S-phase fraction and DNA ploidy. We examined apoptosis by the TUNEL method using flow cytometer, bcl-2 oncoprotein by immunohistochemistry and clinicopathological features in 101 resected advanced gastric carcinomas, which were not treated by preoperative chemotherapy or radiotherapy. DNA ploidy and S-phase fraction were also determined by flow cytometry. Among these factors, only the S-phase fraction showed a correlation with the histological stage of gastric carcinoma. The expression of bcl-2 oncoprotein was significantly correlated with a low apoptotic positive cell fraction and frequently observed in undifferentiated cell type carcinoma than differentiated type. The S-phase fractions of undifferentiated cell type were greater than those of differentiated cell type and showed a tendency of a reverse correlation with apoptosis. These results indicate that apoptosis which is regulated bcl-2 has some influence on the proliferative activity of gastric carcinoma.

収録刊行物

• 日本消化器外科学会雑誌

  日本消化器外科学会雑誌 29 (11), 2092-2097, 1996

  一般社団法人 日本消化器外科学会

キーワード

• apoptosis of advanced gastric cancer
• <I>bcl</I>-2 oncoprotein and apoptosis

詳細情報

• CRID: 1390282679890645504
• NII論文ID: 130004116907
• NII論文ID: 110001320968
• NII書誌ID: AN00192066
• DOI: 10.5833/jjgs.29.2092
• ISSN: 13489372
• ISSN: 03869768
• Web Site: https://www.jstage.jst.go.jp/article/jjgs1969/29/11/29_11_2092/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997085349
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可