肝硬変例におけるトリメタジオン負荷試験とChild‐Pugh scoreとの対比について

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  • Comparison of Trimethadione Tolerance Test and Child-Pugh Score in Patients with Liver Cirrhosis.

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In this study, we examined the relationship between the trimethadione (TMO) tolerance test and the Child-Pugh score in patients with liver cirrhosis to determine if there is an advantage of the TMO tolerance test. The TMO tolerance test is based on the serum dimethadione (DMO)/TMO ratio (DMO is the only metabolite of TMO) 4 hours after oral administration of TMO. The DMO/TMO ratios were 0.33±0.07 in group A of the Child-Pough score, 0.26±0.10 in group B and 0.11±0.06 in group C. These defferences reached statistical significance (p<0.005). There was a significant correlation (r=- 0.186, p<0.0001) between the serum DMO/TMO ratio and the Pugh score. These data show that the TMO tolerance test is as useful for assessing the severity of liver cirrhosis as the Child-Pugh score.

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