HLA ALLOIMMUNIZATION OF SURGICAL PATIENTS BY TRANSFUSION WITH BEDSIDE LEUKOREDUCED BLOOD COMPONENTS
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- OHTO HITOSHI
- Division of Blood Transfusion and Transplantation Immunology, Fukushima Medical University
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- NOMIZU TADASHI
- Collaborative Study Group
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- KURODA FUSAKUNI
- Collaborative Study Group
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- HOSHI TAKETOSHI
- Collaborative Study Group
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- ROKKAKU YUICHI
- Collaborative Study Group
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High efficiency leukocyte reducing filters can remove more than 99.9-99.99% of white cells from cellular blood components and are considered to be effective in decreasing HLA alloimmunization of patients with haematological malignancies.<br>A multi-institution study was performed to determine whether white cell filtration would also be effective in preventing alloimmunization in surgical transfusion recipients. Patients who were to receive red cell blood transfusions during and/or within 48 hours after surgery were randomly assigned to receive red cells/fresh frozen plasma that had been leukoreduced using a high efficiency filter at the bedside or buffycoat-depleted red cells transfused through an aggregate filter.<br>Of 87 patients with no alloantibodies at entry, 17% (8/47) of those in the leukoreduction group, who received a mean of 0.3×106 leukocytes as a result of their transfusions, produced lymphocytotoxic antibodies at day 14 after transfusion, compared to 5% (2/40) in the buffycoat-depleted group, who had received a mean of 1,234.2×106 leukocytes. This difference in the alloimmunization rate between the two arms was not statistically significant.<br>Reduction of leukocytes by bedside filtration does not appear to be effective in preventing HLA alloimmunization in surgical transfusion recipients. The alloimmunized cases suggest that an indirect allorecognition pathway may be involved in the formation of anti-HLA. Further measures are needed to reduce alloimmunization of immunocompetent patients.
収録刊行物
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- 福島医学会
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福島医学会 49 (1), 45-54, 2003
福島医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681280919040
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- NII論文ID
- 110001374233
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- NII書誌ID
- AA0065246X
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- COI
- 1:CAS:528:DC%2BD3sXovFGltro%3D
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- ISSN
- 21854610
- 00162590
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- PubMed
- 14603951
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- 使用不可