Monitoring Plasma Neuropeptide-Like Immunoreactivity Levels in a Patient Given Hange-koboku-to for a Week for Swallowing Reflex Disorder
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- Naito Takafumi
- Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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- Itoh Hiroki
- Department of Clinical Pharmacy, Oita University Hospital
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- Katagiri Fumihiko
- Department of Clinical Pharmacy, Oita University Hospital
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- Hashimoto Hisakuni
- Division of Hospital Pharmacy, Hamamatsu University School of Medicine
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- Takeyama Masaharu
- Department of Clinical Pharmacy, Oita University Hospital
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Hange-koboku-to (Banxia-houpo-tang), a Traditional Chinese Medicine remedy, has been used to treat swallowing reflex disorder, and it has been recently suggested that one of the mechanisms for the empirical effect of Hange-koboku-to involves humoral changes in neuropeptide levels. We suggested to administer Hange-koboku-to to a 70-year-old man with swallowing reflex disorder due to multiple cerebral infarctions and investigated the relationship between changes in plasma-neuropeptide-like immunoactivity (LI) levels and swallowing for a period of 1 week. On the 4 th and 7 th day of administration, the patient' s plasma calcitonin gene-related peptide (CGRP) -LI levels were twice the concentration on day 0 and Hange-koboku-to had increased the patient' s plasma substance P-LI levels approximately 5-fold on these 2 days. The plasma substance P-LI levels on days 4 and 7 were close to the levels (mean±SD) of elderly subjects without swallowing reflex disorder. Following the administration of Hange-koboku-to, plasma somatostatin-LI and vasoactive intestinal polypeptide (VIP) -LI levels in this patient exceeded those of elderly subjects without swallowing reflex disorder (mean + SD). With regard to symptoms, the patient' s difficulty in swallowing had disappeared on the third day of administration.<BR>This study suggests that Hange-koboku-to relieves swallowing reflex disorder by stimulating neuropeptidergic nerves and that this effect is achieved within 1 week of administration. However, we need to study more cases of the use of Hange-koboku-to for swallowing reflex disorder and further investigate the relationship between changes in neuropeptide-LI levels and its pharmacological effects.
収録刊行物
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- 医療薬学
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医療薬学 31 (7), 585-590, 2005
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204777038464
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- NII論文ID
- 110001376941
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- NII書誌ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- NDL-Digital
- CiNii Articles
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