テブフェンピラドのコイにおける吸収・分布・代謝・排泄
書誌事項
- タイトル別名
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- Uptake, Distribution, Metabolism and Excretion of Tebufenpyrad by Carp, <i>Cyprinus carpio</i>
- テブフェンピラドのコイにおける吸収・分布・代謝・排泄〔英文〕
- テブフェンピラド ノ コイ ニ オケル キュウシュウ ブンプ タイシャ ハイセ
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Uptake, distribution, metabolism and excretion of tebufenpyrad [N-(4-tert-butylbenzyl)-4-chloro-3-ethyl-1-methylpyrazole-5-carboxamide, Pyranica®], a synthetic acaricide, were studied with carp. Fish were exposed to 14C-tebufenpyrad treated water (1.2μg/l) for 28 days, followed by 14 days period for depuration. Bioconcentration factors (BCFs) of 14C reached a steady-state plateau within 7 days of exposure and its maximum BCF was 864. HPLC analysis showed that less than 4% of the 14C in whole fish was tebufenpyrad to give the maximum BCF of 29. Gall bladder bile contained the highest concentration of 14C, followed by gastrointestinal tract with the contents and hepatopancreas. Tebufenpyrad was not detected in the bile. An enzymatic treatment suggested that 84% of the 14C in bile were β-glucuronic acid conjugates. Major metabolic reactions of tebufenpyrad by carp were hydroxylation on the tert-butyl moiety, followed by oxidation to the carboxyl group and conjugation of the resultant metabolites with glucuronic acid. During the depuration phase, more than 98% of 14C were excreted from fish within 7 days with a half-life of 0.5 days. The results of this study strongly suggest that active biotransformation and excretion play important roles to lower the bioaccumulative potential of tebufenpyrad by carp.
収録刊行物
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- 日本農薬学会誌(Journal of Pesticide Science)
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日本農薬学会誌(Journal of Pesticide Science) 19 (2), 93-101, 1994
日本農薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282680187053312
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- NII論文ID
- 110001712719
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- NII書誌ID
- AN00196227
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- ISSN
- 03851559
- 13490923
- 1348589X
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- NDL書誌ID
- 3882860
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- データソース種別
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- JaLC
- IRDB
- NDL
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- NDL-Digital
- CiNii Articles
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