Large doses of thalidomide are effective for inhibiting mechano-allodynia after the onset of neuropathic pain

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Thalidomide has a therapeutic effect if administered before neuropathic pain occurs, however, it has no effect if administered after. This was thought to result from the completed formation of a cytokine cascade. We investigated the possibility that neuropathic pain may be treated by the experimental administration of a large dose thalidomide after pain onset. We administered 200 mg・kg^-1, 100 mg・kg^-1, and 0 mg・kg^-1 of thalidomide to rats in which neuropathic pain had occurred due to CCI, and measured its effect on mechanoallodynia and cold-allodynia 7, 14, and 21 days after administration. We found that only the group that had received the 200 mg・kg^-1 of thalidomide showed an improvement in mechano-allodynia. This may have been caused by antiedema effect of thalidomide.

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