Effect of clonidine on a model of experimental neuropathic pain with neuritis

DOI 参考文献8件
  • Sakuma Yasushi
    Department of Anesthesiology, Osaka Dental University
  • Kato Yasuhiko
    Department of Anesthesiology, Osaka Dental University
  • Oka Masaki
    Graduate School of Dentistry(Anesthesiology), Osaka Dental University
  • Hashimoto Kayoko
    Graduate School of Dentistry(Anesthesiology), Osaka Dental University
  • Yamashita Tomoaki
    Graduate School of Dentistry(Anesthesiology), Osaka Dental University
  • Kan Yuki
    Graduate School of Dentistry(Anesthesiology), saka Dental University
  • Ueda Yutaka
    Department of Anesthesiology, Osaka Dental University

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We examined the effect of clonidine with complete Freund's adjuvant (CFA) on neuritis in Sprague-Dawley rats using behavior assays. The animals were anesthetized and the common sciatic nerves were exposed bilaterally after intraperitoneal injection of 50μg/kg clonidine or saline. The left nerve was wrapped in a band of sterile hemostatic oxidized cellulose saturated with 50μL CFA. The right nerve was only exposed. Intraperitoneal injection of clonidine or saline were administered every 12 hours for a total of eight times. The response of the rats was checked 12 hours after the last injection. We found that cold-allodynia and mechano-hyperalgesia, but not mechano-allodynia, were depressed in the rats that had received clonidine.

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