Compatibility of Clonazepam with Other Ingredients

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  • 医薬品の配合変化に関する研究第2報クロナゼパム細粒

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Abstract

Compatibility of Clonazepam granule with other agents was studied on the basis of weight change and UV spectroscopy. Thirteen mixtures of Clonazepam granule and different agents, wrapped in white paraffine paper, were left to stand for a long time at three grades of constant temperature and constant relative humidity (30°, 92%; 25°, 75%; 5°, 52%). Change with time in stability of respective mixtures was examined. Three of the 13 mixtures melted partially in 3 days at 30° but that was not caused by Clonazepam granule. It is especially interesting that the weight of the mixture of Clonazepam granule with Mino-Aleviatin (30°, 92%; 25°, 75%) decreased gradually with time. That was attributable to the sublimation of Mino-Aleviatin.

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