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Commercial cephalexin capsules were compared in terms of their in vivo absorption in humans, as well as of weight variations, disintegration and dissolution rates. No significant difference was found in dissolution rates among five of the six brands examined, but in the remaining one brands maximum plasma concentration was lower and the time for the concentration to reach the maximum level was varied between capsulles. That may be attributed to slow dispersion of the granule taken out from the capsules. Bioavailability of cephalexin, a readily absorbable substance, may largely depend on lubricants or granulation methods.