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Photodegradation of vitamin K_1 and K_2 injections during preservation and in intravenous admixtures was investigated by high-pressure liquid chromatography. When exposed to fluorescent light (500 lux), 50% of commercial product (10 mg) of vitamin K_1 decomposed in about 15 days, compared with about 10 days for the 50% decomposition of vitamin K_2 product. In the intravenous admixtures for drip infusion, the residual rate after sunlight irradiation (2,000 lux) for 3 hours was 43-63% for K_1 and 31-44% for K_2. Therefore, intravenous admixtures containing these light-unstable injections require shading during drip infusion. In Osaka University Hospital, the light-resistant covers of containers for injections are used for this purpose.