ノイキノン顆粒の配合変化に関する研究  [in Japanese] Compatibility of Neuquinon Granule with Other Ingredients  [in Japanese]

Compatibility of Neuquion granules in combination with each of 31 adjuvant drugs was investigated in terms of change in appearance and weight. The mixtures, wrapped with white wax paper or polyethylene-laminated cellophan paper, were kept at 35°with relative humidity of 92% or 25°with 75%, respectively. Changes were examined immediately after compounding, and 2, 4, 7 and 14 days after. Some changes which could affect administration were observed in many combinations. But no significant changes attributable to the granules were detected. Marked change in appearance was seen after combination with Marzulene-S granule, but it was confirmed by thin layer chromatography that no chemical change took place between the two products.