Multiple Digestive Enzymes : Activity and Inactivation of Digestive Enzymes

NDL Digital Collections
  • Fukuchi,Hiroshi
    Department of Pharmaceutical Services, Hiroshima University Hospital
  • Yoshida,Minoru
    Department of Pharmaceutical Services, Hiroshima University Hospital
  • Shintani,Hiromichi
    Department of Pharmaceutical Services, Hiroshima University Hospital
  • Ikeda,Hiroaki
    Department of Pharmaceutical Services, Hiroshima University Hospital
  • Seki,Yoko
    Department of Pharmaceutical Services, Hiroshima University Hospital
  • Kawakita,Yurie
    Department of Pharmaceutical Services, Hiroshima University Hospital

Bibliographic Information

Other Title
  • 総合消化酵素剤の検討 : 酵素活性とその失活

Search this article

Abstract

The activity of α-amylase, glucoamylase, protease, lipase and cellulase contained in such commercial multiple digestive enzyme preparations as Eczema, Excels, Politesse and Toughmac-E capsule was determined. These digestive enzymes were immersed in citric acids solution with a pH of 2.0 for 5 minutes and the loss rate of enzyme activity due to acidic environment was determined. Each digestive enzyme had characteristic activity against each substrate. However, all the four preparations showed a 100% loss in glucoamylase activity, while the loss rate of α-amylase, protease, lipase and cellulase ranged from 30 to 76%. Therefore, multiple digestive enzyme preparations should be coated with materials suitable for each enzyme contained in view of changing pH in digestive tract.

Journal

  • 病院薬学

    病院薬学 4 (1), 31-34, 1978-05-20

    日本病院薬剤師会

Details 詳細情報について

Report a problem

Back to top