紫外線照射によるアクリノールの抗菌活性の変化  [in Japanese] Effect of Ultraviolet Irradiation on the Antibacterial Activity of Acrinol  [in Japanese]

A study was made to investigate whether the change in color of acrinol aqueous solution by light affects bacterial potency of acrinol. Acrinol was decomposed rapidly by the irradiation with high pressure lamp when its initial concentrations were lower, but the decomposition was slowed down at higher initial concentrations. Four resultant products were observed by thin-layer chromatography and major one of them was isolated by column chromatography. The bactericidal potency was expressed in terms of minimum inhibitory concentration (MIC) against Staph. aureus 209-P RIMD. The MIC of the UV-irradiated acrinol solutions remained in the range of 1O.O-12.5μg/ml which was on a level with that of control acrinol solution. The range was irrelevant to the initial concentrations. The major compound isolated by column chromatography also showed similar MIC.