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Changes in weight of drops of purified water with the method of handling of dropping bottles and types of bottles were investigated. Two types of dropping bottles on the market were used : Kreuz Tropfchen (T type) and a bottle made of glass (E type). The volume of purified water in the dropping bottles gave almost no effect on the weight of 20 drops of purified water. When the angle of the inclination of the dropping bottles was increased from 30°to 45°and 60°, the weight of drops of purified water showed a tendency to increase in the measurement with T type and to decrease with E type. Thus the weight changed in parallel with dropping speed. The range of changes in weight depended on the types of dropping bottles and probably on the angle of dropping surface at the tip of dropping bottles.