高速液体クロマトグラフィーによる吸入用液剤中の気管支拡張剤の定量

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  • 川勝,一雄
    京都大学結核胸部疾患研究所附属病院薬剤部
  • 桑田,宏
    京都大学結核胸部疾患研究所附属病院薬剤部

書誌事項

タイトル別名
  • High Pressure Liquid Chromatographic Analyses of Sympathomimetic Bronchodilators in Inhalant Preparations

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抄録

High pressure liquid chromatographic determination of clorprenaline hydrochloride, isoproterenol hydrochloride, orciprenaline sulfate, salbutamol sulfate and trimetoquinol hydrochloride in inhalant preparations was made using a Zorbax ODS reverse phase column and acetonitrile-phosphate buffer (pH 2.3) as mobile phase. The peaks of the additives and decomposition products in the solutions on chromatograms did not interfere with those of the bronchodilators. The coefficients of variation for analytical values, calculated from 2 different concentrations of the bronchodilators, ranged from 0.3 to 2.9%・ Moreover, good recoveries (95.5-101.9%) were obtained from Alevaire or Bisolvon Solution. Thus, the methods can be applied to the evaluation of these inhalant preparations.

収録刊行物

  • 病院薬学

    病院薬学 9 (1), 40-44, 1983-02-20

    日本病院薬剤師会

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