混合製剤中のBetamethasone-17-valerateの安定性  [in Japanese] Stability of Betamethasone-17-valerate in Admixtures  [in Japanese]

Stability of betamethasone-17-valerate (BM-17-V) in admixtures of Rinderon-VG ointment with other ointment or cream was studied. Determination of BM-17-V was made by high performance liquid chromatography, and the result of determination, as well as change in pH value and appearance, was recorded immediately after admixing, and 2, 4 and 8 weeks after storage at room temperature. Further, stability of BM-17-V and change in appearance were studied 1 week after storage at 37℃. Significant change was not observed in any test item, thus indicating that Rinderon-VG ointment is compatible with other ointment or cream examined.