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A midazolam lollipop was prepared to improve the QOL of pediatric patients given premedication and to expect absorption of midazolam from oral mucosa. A mixture of sucrose, glutinous starch syrup and orange flavor was employed to prepare the midazolam lollipop for masking the bitter taste of midazolam. In the quality test, the coefficient of variation of midazolam concentration in the lollipop ranged from 1.81 to 6.53 CV%. In the clinical examination, 50 patients, aged 6 months to 6 years oid, were recruited. Children weighing under 15 kg were given one lollipop and over 15 kg were given two at 30 minutes before entering the operating room. 42 patients were willing to accept the midazo]am lollipop and we consequently obtained the sedate condition satisfactorily at the induction of anesthesia. In conclusion, the midazolam lollipop may constitute a more effective dosage form as a premedicant for pedriatric patients than previous forms and it may be less disturbing mentally and physically because most children like lollipops.