ジソピラミド服用入院患者における徐放剤と非徐放剤との血中濃度のバラツキの比較  [in Japanese] Comparison of Variation in Serum Disopyramide Concentration between Inpatients Administered Sustained-release and Non-sustained Release Preparations of Disopyramide  [in Japanese]

The variation in serum disopyramide concentration at early morning (6 : 00) in inpatients administered 300mg per day of sustained-release disopyramide tablet (Rthmodan R, preparation A) or the same dose of non sustained-release disopyramide capsule (Rthmodan, preparation B) was studied. Twenty-one inpatients, whose mean age was 68.4±10.2 (SD) yr and mean body weight was 52.0±7.6kg, received preparation A (q 12 hr at 7 : 00 & 19 : 00). Nineteen inpatients, whose mean age was 68.3±12.9 yr and body weight was 54.0±11.3kg, received preparation B (tid at 7 : 00, 12 : 00 & 19 : 00). No differences were observed in the mean ratio of serum disopyramide concentration at 6 : 00 to dose between inpatients receiving preparations A and B, although a signficant difference was observed in its variation. When the intra-individual variability in inpatients monitored more than three times was compared, the CV was 4.93±1.74% (SD) in inpatients receiving preparation A versus 21.8±7.8% in inpatients received preparation B. Therefore, this suggests that the variation in serum disopyramide concentration in inpatients receiving preparation A was significantly decreased over that of preparation B.