N-(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5')のラットの腎機能に及ぼす影響

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  • EFFECT OF N-(3', 4'-DIMETHOXYCINNAMOYL) ANTHRANILIC ACID (N-5') ON RENAL FUNCTION IN RATS

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In order to investigate the effect of N-(3', 4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a new anti-atopic agent, on renal functions, the present experiment was carried out using Wistar male rats. N-5' was given orally at doses of O (control), 200, 400 and 800 mg/kg for 5 weeks. For the purpose of the regression test, four or five animals in each group were kept without drug for 5 weeks after the termination of drug administration. One fatality, which showed an inhibition of body weight gains and a slight increase in water intake, was found only in the animals treated with 800mg/kg. In urinalysis at the 1st and 3rd week of experimental period, a slight increase in urine volume and decreases in specific gravity and electrolytes were found in the animals treated with 800 mg/kg, but not at the 5th week and in the regression test. Abnormalities were not observed in renal concentration test, PSP excretion test, urea nitrogen level in serum and 24hr-endogenous creatinine clearance test. In histopathological examination, no lesions could be seen. On account of these results, N-5' seemed not to have the potential of renal toxicity.

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