ACUTE TOXICITY OF CHLOROPEPTIDE, A HEPATOTOXIC METABOLITE OF PENICILLIUM ISLANDICUM SOPP

• UENO Yoshio

• ITO Teruo

• HASHIMOTO Naokazu

• UENO Ikuko

抄録

Chlorine-containing cyclic pentapeptide (Cl-peptide) is one of the hepatotoxic and hepatocarcinogenic metabolites of Penicillium islandicum Sopp. The sc LD_&lt50&gt values of Cl-peptide for mice, rats and guinea-pigs were all in the range of 0.5 mg/kg, while the po LD_&lt50&gt values for mice and rats were around 5mg/kg. The newborn mice were less susceptible than the adults. The acutely intoxicated mice and rats showed a marked elevation of serum transaminases and a transient increment followed by a marked decline of blood glucose level. The liver of animals pretreated with the toxin showed marked declines of glycogen and microsomal protein and an increase of cyclic AMP content. Tracer experiments revealed a preferencial accumulation of the toxin in the liver of mice and an excretion through feces. Correlation between the hepatotoxicity and the hepato-accumulation of the cyclic peptide was discussed.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 2 (4), 349-362, 1977

  一般社団法人　日本毒性学会

キーワード

• Toxicology

詳細情報

• CRID: 1390282679879673984
• NII論文ID: 110001803831
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.2.349
• COI: 1:CAS:528:DyaE1cXktFyju7o%3D
• ISSN: 18803989
• ISSN: 03881350
• Web Site: http://www.jstage.jst.go.jp/article/jts1976/2/4/2_4_349/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可