Effect of estrogen on liver plasma membrane in rats.

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The effect of estrogen on plasma membrane was investigated using the primary cultured rat hepatocytes treated with carbon tetrachloride (CCl4) and the isolated plasma membrane of rat liver. 17 β-Estradiol (E2), at concentrations of 10-10M to 10-4M, 10-8M to 10-6M and 10-12M to 10-4M, had an inhibitory effect on the CCl4-induced leakage of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, respectively from primary cultured rat hepatocytes. Diethylstilbestrol, which caused inhibition at a dose of 10-4, did not inhibit any enzyme leakage ;at any further concentrations of 10-12M to 10-6M. In the isolated plasma membrane of rat liver, Mg2+- and Na+, K+- adenosine triphosphatase activity was increased by E2 treatment at concentrations of 10-6M and 10-4M.

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