Studies on the therapeutic effect of 2-pyridine aldoxime methiodide(2-PAM) in mammals following organophosphorus compound-poisoning. (Report III): distribution and antidotal effect of 2-PAM in rats.

• UEHARA Sachiko

• HIROMORI Toshihiko

• ISOBE Naohiko

• SUZUKI Takashi

• KATO Terushige

• MIYAMOTO Junshi

抄録

The metabolic fate of 2-PAM and its antidotal effect on organophosphorus compound poisoning in rats were studied. When ¹⁴C-2-PAM was administered intravenously, the amount of ¹⁴C reaching the brain was small. Following administration by intramedullary injection, ¹⁴C was present in high concentrations in the brain, and 72-90% of the ¹⁴C present in the brain corresponded to the unchanged form of 2-PAM. 2-PAM was rapidly excreted into the urine and feces following either intramedullary or intravenous administration. The half-life of 2-PAM in the brain following intramedullary administration was 1.52 hr. Intramedullary administration of 2-PAM to rats poisoned with fenitrothion or malathion enabled their survival and induced reactivation of brain cholinesterase.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 18 (4), 265-275, 1993

  一般社団法人　日本毒性学会

キーワード

• Antidotal study

詳細情報

• CRID: 1390001204901045632
• NII論文ID: 110001805349
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.18.4_265
• ISSN: 18803989
• ISSN: 03881350
• PubMed: 8295230
• Web Site: http://www.jstage.jst.go.jp/article/jts1976/18/4/18_4_265/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995047321
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可