Effect of hyperprolactinemia induced by pituitary grafts or castration on porphyrin content of the mouse Harderian gland.
-
- KAJIMURA Tetsuyo
- Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd.
-
- SATOH Hiroshi
- Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd.
-
- WATANABE Gen
- Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
-
- TAYA Kazuyoshi
- Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology
この論文をさがす
抄録
The histology and porphyrin concentrations of Harderian glands and plasma prolactin levels were examined in B6C3F1 mice castrated or isografted with pituitaries in combination with the administration of bromocriptine (2-bromo-á-ergocryptine), a potent suppressor of prolactin. Four pituitaries were transplanted underneath the bilateral kidney capsules of each mouse. Furthermore, we investigated Harderian porphyrins and plasma testosterone levels in mice that were castrated or treated with neuroleptic butyrophenone (timiperone), a potent accelerator of prolactin, and treated concurrently with bromocriptine. Light microscopically, pituitary grafts increased the concretion of porphyrin pigments within the Harderian gland lumina. Pituitary grafts or castration increased both Harderian porphyrin concentrations and plasma prolactin levels compared with the intact control mice. In pituitary-grafted or castrated mice, bromocriptine distinctly prevented the rise in both porphyrins and prolactin levels. Administration of butyrophenone did not result in any marked change in testosterone levels, although Harderian gland porphyrins were significantly increased. The present results indicate that in mice prolactin stimulates the porphyrin production of the Harderian gland and has an important role in the regulation of Harderian gland porphyrins.
収録刊行物
-
- The Journal of Toxicological Sciences
-
The Journal of Toxicological Sciences 26 (3), 151-161, 2001
一般社団法人 日本毒性学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204900349184
-
- NII論文ID
- 110001806916
-
- NII書誌ID
- AN00002808
-
- COI
- 1:CAS:528:DC%2BD3MXnsVyns7w%3D
-
- ISSN
- 18803989
- 03881350
-
- NDL書誌ID
- 5875911
-
- PubMed
- 11552298
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可