損傷脊髄修復のための基礎的実験：血小板由来創傷治癒因子（ＰＤＷＨＦ）による生体内血管新生

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タイトル別名
  • Experimental Study for Recovery of Injured Spinal Cord. In Vivo Angiogenesis by Platelet Derived Wound Healing Fomula (PDWHF).
  • ソンショウ セキズイ シュウフク ノ タメ ノ キソテキ ジッケン ケッショウ
  • <i>In Vivo</i> Angiogenesis by Platelet Derived Wound Healing Formula (PDWHF)
  • 血小板由来創傷治癒因子(PDWHF)による生体内血管新生

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The main purpose of this study was to investigate the usefulness of platelet derived wound healing formula (PDWHF) in experimentally induced spinal cord injuries in cats. The injury model in 10 adult cats consisted of the placement of three 22 gauge teflon catheter sheaths into the spinal cord at the L2 level. Administration of PDWHF was achieved by coating theses sheaths with PDWHF in Hydron. Three animals were used as controls. In the 7 remaining cats, administration of PDWHF was double blinded. Cats were sacrificed at 3 weeks after injury and injured spinal cord segments were excised for histologic evaluation. Electrophysiologic and clinical motor function were evaluated throughout the period of observation. Evoked potentials in both groups indicated incomplete spinal cord lesions due to insertion of the needles. There appeared to be improvement of the evoked response and clinical function as a result of administration of PDWHF at 3 weeks after injury, though there was no significance. The histologic findings in the PDWHF group showed significant new vessel formation as well as dilation around the injured site. This neovascularization, both qualitative and quantitative, was noted in the PDWHF group. This information with a limited injury and simple delivery system for growth factor would suggest that there is neovascularization occurring as a result of PDWHF administration.

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