視床下部過誤腫による女児思春期早発症の1例

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  • Hypothalamic Hamartoma associated with Precocious Puberty
  • Case Report

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A hypothalamic hamartoma associated with true precocious puberty in a 2-year-old girl is reported. Following subtotal removal of the tumor, endocrinological abnormalities as well as clinical manifestations of precocious puberty were restored to normal. Although the immunofluorescence study of the specimen was negative, ultrastructural studies revealed dense core vesicles of approximately 100 nm in size in the neurons. The mechanisms of precocious puberty in patients with a hypothalamic hamartoma are briefly discussed.

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