Glucose Consumption and Rate Constants for <SUP>18</SUP>F-fluorodeoxyglucose in Human Gliomas
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- ISHIKAWA Masatsune
- Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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- KIKUCHI Haruhiko
- Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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- NAGATA Izumi
- Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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- YAMAGATA Sen
- Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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- TAKI Waro
- Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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- YONEKURA Yoshiharu
- Departments of Nuclear Medicine, Faculty of Medicine, Kyoto University
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- NISHIZAWA Sadahiko
- Departments of Nuclear Medicine, Faculty of Medicine, Kyoto University
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- IWASAKI Yasushi
- Departments of Nuclear Medicine, Faculty of Medicine, Kyoto University
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- MUKAI Takao
- Departments of Nuclear Medicine, Faculty of Medicine, Kyoto University
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抄録
To investigate the value of direct measurement of the rate constants by performing 18F-labeled fluorodeoxyglucose (FDG) studies of glucose consumption in human gliomas in vivo, a kinetic method with 3- and 4-parameter rate constant models for FDG uptake was used to analyze data from dynamic scans obtained by positron emission tomography after injection of FDG into 14 patients with glioma. The results were compared with those obtained by the autoradiographic method using 3- and 4-parameter rate constant models. There were no significant differences in the glucose consumption calculated by the four different methods both in the gliomas and in the contralateral intact cortex. It was found that the rate constant k4* could be neglected in calculation of glucose consumption in gliomas as well as in the contralateral intact cortex. The rate constant k3*, an index of hexokinase function, was higher in malignant gliomas than in benign gliomas and was close to that in the contralateral cortex. This study indicates that the 3-parameter autoradiographic method, which is the most common one used in clinical practice, is reliable for the calculation of glucose consumption in human gliomas. Furthermore, direct measurement of the regional rate constants for FDG by the kinetic method was found to be useful for evaluation of the biochemical and physiological characteristics of human gliomas in vivo.
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 30 (6), 377-381, 1990
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001205054238464
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- NII論文ID
- 110002278074
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- NII書誌ID
- AN00358613
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- COI
- 1:STN:280:By6D2czjsFc%3D
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- ISSN
- 13498029
- 04708105
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- PubMed
- 1700316
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可