Absence of Response to Hypothalamic Stimulation Test in Brain Death

• KINOSHITA Yoshihiro

  Department of Traumatology, Osaka University Medical School

• GO Kyoto

  Emergency Center of Hyogo Prefectural Nishinomiya Hospital

• YOSHIOKA Toshiharu

  Department of Traumatology, Osaka University Medical School

• SUGIMOTO Tsuyoshi

  Department of Traumatology, Osaka University Medical School

抄録

Immunoreactive corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone (GHRH) are present in the plasma of the brain dead patients. These hypothalamic hormones may reflect some residual brain function after brain death. To examine the hypothalamic function, insulininduced hypoglycemia and arginine infusion were performed in brain dead patients. Plasma CRH and GHRH were present initially, but levels did not increase significantly for 120 minutes after insulin injection. GH, adrenocorticotropic hormone, and cortisol levels did not increase either. Arginine load did not induce GH. These results suggest that hypothalamic hormones in the plasma after whole brain death do not reflect hypothalamic functions. The hormones may originate from extrahypothalamic sources such as the pancreas or adrenal gland.

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 32 (3), 153-156, 1992

  一般社団法人 日本脳神経外科学会

キーワード

• brain death
• corticotropin-releasing hormone
• growth hormone-releasing hormone
• arginine
• hypoglycemia
• vasopressin

詳細情報

• CRID: 1390001205052875904
• NII論文ID: 110002278304
• NII書誌ID: AA10905437
• DOI: 10.2176/nmc.32.153
• COI: 1:STN:280:By2A3MbitVA%3D
• ISSN: 13498029
• ISSN: 04708105
• PubMed: 1377798
• Web Site: http://www.jstage.jst.go.jp/article/nmc1959/32/3/32_3_153/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1993106096
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可