Proliferative Potential of Malignant Glioma Cells Before and After Interstitial Brachytherapy
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- 国塩 勝三
- 香川医科大学脳神経外科
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- MATSUMOTO Kengo
- Department of Neurological Surgery, Okayama University Medical School
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- HIGASHI Hisato
- Department of Neurological Surgery, Okayama University Medical School
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- ADACHI Hisashi
- Department of Neurological Surgery, Okayama University Medical School
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- TAMIYA Takashi
- Department of Neurological Surgery, Okayama University Medical School
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- FURUTA Tomohisa
- Department of Neurological Surgery, Okayama University Medical School
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- OHMOTO Takashi
- Department of Neurological Surgery, Okayama University Medical School
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The viability of tumor cells in radionecrotic tissue after interstitial brachytherapy (BRTX) was evaluated using immunohistochemical markers of proliferative potential in primary and recurrent tumors. Tumor specimens from 30 patients with malignant gliomas (14 anaplastic astrocytomas, 16 glioblastomas) taken before and after BRTX were examined using MIB-1 monoclonal antibody. Histological examination of specimens obtained by craniotomy or stereotactic biopsy after BRTX revealed tumor recurrence in 18 patients and radionecrosis in 12 patients including two with pure radionecrosis and 10 with a mixture of both tumor and radionecrosis. The MIB-1 index of the tumors with radionecrosis was 7.6 ± 5.5%, and that of the primary tumors was 17.0 ± 11.2%, showing a significant difference (p < 0.05). There was no significant difference between the MIB-1 index of the primary tumors with local recurrence after BRTX and the primary tumors which underwent radionecrosis. Although morphologically viable tumor cells were found in the radionecrotic tissue, BRTX causes a reduction in the proliferative potential of these tumor cells.
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 39 (5), 341-349, 1999
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001205052269312
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- NII論文ID
- 110002279756
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- NII書誌ID
- AN00358613
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- ISSN
- 13498029
- 04708105
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- PubMed
- 10481436
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可