Carcinostatic Effect of Extracts from Human Gastric Cancer

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  • 船岡 宏明
    Department of Surgery, The Research Institute for Nuclear Medicine and Biology, Hiroshima University
  • 江崎 治夫
    Department of Surgery, The Research Institute for Nuclear Medicine and Biology, Hiroshima University
  • 荒木 文雄
    Department of Pathology, Yamaguchi University School of Medicine
  • 杉原 芳夫
    Department of Pathology, Hiroshima University School of Medicine

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Saline extracts from human gastric cancer divided into two parts, one of which was irradiated by X-ray of 2000 r, before homogenization, were fractionated with EtOH, in which S, was 30% vol. ppt., S, was 30-70% vol. ppt., and S3 was supernatant. Further, S1 and S2 were fractionated with (NH4)2SO4 into P1 (30% sat. ppt.), P2 (30-50% sat. ppt.), P3 (50-700/ sat. ppt.), and P4 (supernatant).<BR> The S2P1 and S2P2 fractions non-irradiated inhibited the growth of subcutaneous solid Ehrlich ascites tumor in mice, which were respec tively significant at the level of 10% and 5%, but the same fractions irradiated lost the growth inhibitory activity.<BR> The S2P3 fraction irradiated inhibited the growth of solid tumor at the level of 20%, and was different from the equivalent non-irradiated fraction having mitosis promoting activity at the significance of 0 .5% <BR>These data may show that malignant tumor contains the growth inhibiting substance which is not species specific, and the carcinostatic effect of X-ray irradiation is due to the destruction of balance between growth promoting and inhibiting substances inside of the tumor tissue.

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