Effect of single and fractionated X-irradiation on maze learning ability of mice.

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  • 青山 喬
    滋賀医科大学放射線基礎医学教室
  • 法村 俊之
    長崎大学医学部原爆後障害医療研究施設
  • 中村 剛
    長崎大学医学部原爆後障害医療研究施設
  • 吉川 勲
    長崎大学医学部原爆後障害医療研究施設

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Fifty-six-day-old male ddk mice at the starting of the investigation were used as subjects through the experiment for 64 weeks. After 15 days' preliminary training, and 16 times of weekly trial training using complete maze, 15 mice received a single 224 rads of X-rays (S group), another 15 mice received two 112 rads spaced two weeks apart (F group) and another 15 mice were sham-irradiated (control group). Then those mice were tested on the multiple T-maze with nine-choice points and change of performance was observed in terms of errorchoices by giving one test trial a week. We introduced the concept of "confusional trials" as an index for surmising to what extent mice failed to exhibit good maze learning habits. In the results, the F group showed significantly worse performance than the two other groups at early stages, opposite to it the S group exhibited the same, but at late stages after irradiation. The worse performance of F group should be considered to be due to the psychological after-effect to fractionated irradiation and that for S group could be assumed to be due to the acceleration of aging by the irradiation.

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