Dimethylsulfoxide reduces the X-ray-induced G2 delay in Chinese hamster ovary cells.

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The effects of dimethylsulfoxide (DMSO) on radiation-induced G2 delay and on each stage in mitotic phase were studied. The G2 delay was reduced by the postirradiation treatment of Chinese hamster ovary cells by over 2%. DMSO at 2% had no effect on the progression of the cells through metaphase, anaphase or telophase, when added after mechanical collection of cells at the mitotic phase. DMSO over 5%, and particularly over 7%, led to a retardation at metaphase, with little effect on anaphase or telophase.

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