Lung cancer incidence among Japanese A-bomb survivors, 1950-80.
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- 山本 務
- 放射線影響研究所 広島県医師会
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- KOPECKY KENNETH J.
- Department of Statistics, Radiation Effects Research Foundation The Fred Hutchinson Cancer Research Center
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- 藤倉 敏夫
- 放射線影響研究所長崎支所
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- 徳岡 昭治
- 広島大学医学部第二病理
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- 門前 徹夫
- 広島県病院
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- 西森 一正
- Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine
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- 中島 栄二
- 放射線影響研究所
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- 加藤 寛夫
- 放射線影響研究所
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抄録
The incidence of lung cancer during 1950-80 in a cohort of Japanese A-bomb survivors and controls was investigated. A total of 1, 057 cases were identified; 608 of these diagnoses were based on histopathological examination, and 442 were confirmed by the present investigators. The distributions of histologic types varied significantly between the sexes (p < .001), with adenocarcinoma more frequent among women and epidermoid and small cell carcinoma more frequent among men. The distributions of primary sites did not differ significantly between the sexes. The relative risk (RR) of lung cancer increased significantly with A-bomb radiation dose (p < .0001): based on tentative 1965 dose estimates as revised in 1978 (T65DR) and a linear RR model, the estimated RR at 100 rad (±s.e.) is 1.41 ± 0.09. Among Hiroshima survivors the women experienced radiation-related excess RR nearly twice as great as men (p = .06). RR increased with decreasing age at the time of bombing (ATB; p = .07), and after allowing for this effect, there was no significant evidence that RR varied systematically with attained age. Small cell carcinoma displayed somewhat greater sensitivity to radiation than did adenocarcinoma or epidermoid carcinoma; however the variation between the histology-specific RR functions was not statistically significant (p = .44).
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 28 (2), 156-171, 1987
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680194193280
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- NII論文ID
- 110002326019
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:BieD3srnsVw%3D
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- ISSN
- 13499157
- 04493060
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- HANDLE
- 10069/18914
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- PubMed
- 2822912
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可