Radioprotection by 16,16 Dimethyl Prostaglandin E2 is Equally Effective in Male and Female Mice.

• WALDEN, Jr. THOMAS L.

  Department of Medicine, Fairfax Hospital, Falls Church

• FARZANEH NUSHIN K.

  Department of Medicine , National Naval Medical Center

Abstract

Pretreatment with 16, 16 dimethyl prostaglandin E₂ (DiPGE₂) provides effective protection against radiation and chemical injury. Cytoprotection against chemical injury is known to be influenced by sex factors, and is more effective in females than males. Since prostaglandin metabolism and biological responses to prostaglandin may vary between sexes, studies were conducted to compare DiPGE₂-induced radioprotection in male and female mice.<BR> Pretreatment with 400 μg DiPGE₂/kg body wt substantially enhanced 30-day survival in males and females. There was no significant difference in the LD_50/30 of male and female mice receiving vehicle alone prior to irradiation, 8.34 Gy versus 8.46 Gy, respectively. DiPGE₂ treatment increased the LD_50/30in males to 12.1 Gy, providing a dose modification factor (DMF) of 1.45. Similar increases were observed in females, with a LD_50/30 of 11.6 and a DMF of 1.37. The reported difference in DiPGE₂-induced cytoprotection between males and females exposed to ethanol injury, and the lack of variation in the present radioprotection study suggests that separate mechanisms are involved in the two processes.

Journal

• Journal of Radiation Research

  Journal of Radiation Research 36 (1), 1-7, 1995

  Journal of Radiation Research Editorial Committee

Keywords

• Radioprotection
• cytoprotecion
• 16,16 dimethyl prostaglandin E<SUB>2</SUB>
• sex factors
• bone marrow aplasia

Details

• CRID: 1390001205215782784
• NII Article ID: 110002328063
• NII Book ID: AA00705792
• DOI: 10.1269/jrr.36.1
• COI: 1:CAS:528:DyaK2MXms12lsbk%3D
• ISSN: 13499157
• ISSN: 04493060
• ISSN: http://id.crossref.org/issn/04493060
• PubMed: 7616483
• Web Site: http://academic.oup.com/jrr/article-pdf/36/1/1/2767761/jrr-36-1.pdf
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10915120
• Web Site: https://search.jamas.or.jp/link/ui/1996123954
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • NDL-Digital
  • CiNii Articles
• Abstract License Flag: Disallowed