Relative biological effectiveness of 252Cf radiation as estimated by thymus weight loss.

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  • FEOLA JOSE M.
    Radiation Medicine Department, University of Kentucky Medical Center
  • HWANG HUNG-NIEN
    Radiation Medicine Department, University of Kentucky Medical Center
  • BEACH J. LAWRENCE
    Radiation Medicine Department, University of Kentucky Medical Center
  • MARUYAMA YOSH
    Radiation Medicine Department, University of Kentucky Medical Center

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Abstract

The relative biological effectiveness (RBE) of 252Cf radiation at a low dose rate (LDR) of 21.1 cGy/h was studied for its mixed neutron and gamma radiations vs. LDR 137Cs (70.6 cGy/h) and acute 60Co gamma radiations (123 cGy/min). Dose response was determined by thymus weight loss and showed bi-exponential curves reflecting a sensitive and less sensitive populations to 252Cf, 137Cs and 60Co radiations. The mean lethal doses (D0''s) for the first component were: 252Cf, 74 ± 6 cGy; 137CsS, 108 ± 15 cGy; 60Co, 102 ± 20 cGy; 137Cs and 60Co pooled, 109 ± 26 cGy. The D0''s for the second component were: 252Cf, 375 ± 50 cGy; 137Cs; 619 ± 50 cGy; 60Co, 627 ± 270 cGy; 137Cs and 60Co pooled, 624 ± 56 cGy. The RBE obtained by the ratio of the first component (pooled 137Cs and 60Co to 252Cf) was 1.47 ± 0.14 for n + γ and for neutrons only was 1.70 ± 0.16. The ratio of the doses of 137Cs to 252Cf to obtain a fractional weight change of 50% gave and RBE of 1.70 ± 0.20, and RBEn = 2.04 ± 0.24. The RBE by the ratio of pooled 137Cs and 60Co data to 252Cf to obtain 50% weight loss from all data was estimated to be 3.00 ± 0.60, and RBEn = 4.00 ± 0.80. No dose rate effect was found for LDR 137Cs vs. acute 60Co radiations.

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