Similarity between the Effects of Carbon-ion Irradiation and X-irradiation on the Development of Rat Brain
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- INOUYE MINORU
- Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
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- TAKAHASHI SENTARO
- The 4th Research Group, National Institute of Radiological Sciences
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- KUBOTA YOSHIHISA
- The 4th Research Group, National Institute of Radiological Sciences
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- HAYASAKA SHIZU
- Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
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- MURATA YOSHIHARU
- Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya University
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抄録
The effects of carbon-ion irradiation and X-irradiation on the development of rat brain were compared. Twenty pregnant rats were injected with bromodeoxyuridine (BrdU) at 9 pm on day 18 of pregnancy and divided into five groups. Three hours after injection (day 19.0) one group was exposed to 290 MeV/u carbon-ion radiation by a single dose of 1.5 Gy. Other groups were exposed to X-radiation by 1.5, 2.0 or 2.5 Gy, or sham-treated, respectively. Fetuses were removed from one dam in each group 8 h after exposure and examined histologically. Extensive cell death was observed in the brain mantle from the irradiated groups. The cell death after 1.5 Gy carbon-ion irradiation was remarkably more extensive than that after 1.5 Gy X-irradiation, but comparable to that after 2.0 Gy or 2.5 Gy X-irradiation. The remaining rats were allowed to give birth and the offspring were sacrificed at 6 weeks of age. All of the irradiated offspring manifested microcephaly. The size of the brain mantle exposed to 1.5 Gy carbon-ion radiation was significantly smaller than that exposed to 1.5 Gy X-radiation and larger than that exposed to 2.5 Gy X-radiation. A histological examination of the cerebral cortex revealed that cortical layers II-IV were malformed. The defect by 1.5 Gy carbon-ion irradiation was more severe than that by the same dose of X-irradiation. Although the BrdU-incorporated neurons were greatly reduced in number in all irradiated groups, these cells reached the superficial area of the cortex. These findings indicated that the effects of both carbon-ion irradiation and X-irradiation on the development of rat brain are similar in character, and the effect of 1.5 Gy carbon-ion irradiation compares to that of 2.0-2.5 Gy X-irradiation.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 41 (3), 303-311, 2000
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205217611904
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- NII論文ID
- 110002328725
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:DC%2BD3M3isVCmtA%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 5564138
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- PubMed
- 11210831
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可