A25-122 APPLIED MICRO FLUIDICS : FROM SIMULATION TO SYSTEM PROTOTYPES :

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The paper presents latest developments of selected prototypes, highlighting the importance of a strongly interconnection of the single processes of the development chain. First introducing two different types of micro mixers, relying on interdigital multilamination and on successive split-and-recombination. While the former mixing concept applies for a wide range of Reynolds numbers and for single-and multiphase application, the latter is especially suited for mixing of highly viscous fluids. Furthermore a novel micro reactor for efficient gas / liquid contacting is introduced which utilizes material dependent wettabilities. Feasibility of these so-called surface-directed flows is proven based on numerical simulations and first experimental studies. Finally, a disposable polymer chip for two-dimensional capillary gel electrophoresis is presented. The miniaturized, integrated approach opens up the route to fast, automated and cheap protein analysis. The chosen examples highlight the role of mathematical modeling, application adapted micro fabrication and experimental validation and the interdependence thereof.

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