喘息における気道の閉塞のメカニズムに関する数値シミュレーション Numerical Simulation for Mechanism of Airway Narrowing in Asthma

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抄録

A calculation model is proposed to examine generation mechanism of many lobes on inner-wall of airway in asthmatic patients and to clarify luminal occlusion of the airway inducing difficult breathing. The basement membrane in the airway wall is modeled as two-dimensional thin-walled shell having inertia force due to the mass, and smooth muscle contraction effect is replaced by uniform transmural pressure of the basement membrane. A dynamic explicit finite element method is used as a numerical simulation method. To check validity of the present model, simulation of asthma attack is performed. The number of lobes generated in the basement membrane is increased when the transmural pressure is applied in shorter time. When the remodeling of the basement membrane occurs characterized by thickening and hardening of it, it is demonstrated that the number of lobes is decreased and the occlusion of the airway lumen is progressed further. Comparison of results calculated by the present model with those measured for animal experiments of asthma will be possible.

収録刊行物

  • 日本機械学會論文集. C編 = Transactions of the Japan Society of Mechanical Engineers. C

    日本機械学會論文集. C編 = Transactions of the Japan Society of Mechanical Engineers. C 68(667), 713-719, 2002-03-25

    一般社団法人日本機械学会

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各種コード

  • NII論文ID(NAID)
    110002378397
  • NII書誌ID(NCID)
    AN00187463
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03875024
  • NDL 記事登録ID
    6117001
  • NDL 雑誌分類
    ZN11(科学技術--機械工学・工業)
  • NDL 請求記号
    Z16-1056
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS 
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