Studies on the Activation of Plasmin and the Decrease of Leucocytes

DOI Web Site
  • Tojo Junji
    Department of Internal Medicine, Osaka City University Medical School

Bibliographic Information

Other Title
  • 血漿蛋白溶解酵素Plasmin活性化と白血球減少に関する研究
  • ケッショウ タンパク ヨウカイ コウソ Plasmin カッセイカ ト ハッケッキュウ ゲンショウ ニ カンスル ケンキュウ

Search this article

Abstract

The relation between the plasmin activation and the decrease of leucocytes, especially on the direct effect of the active plasmin against leucocytes were investigated and at the same time, the mechanism of the decrease of leucocytes in anaphylaxis were also studied from the point of plasmin activation. When active plasmin extracted from the blood plasma of the dog was injected into the rabbit, the decrease of the leucocytes, chiefly of granular leucocytes were observed to be developed. When Plasmin was acted directly to leucocytes in vitro, granular leucocytes decreased in number. When plasmin was added to the separated lencocytes and incubated, various changes, such as the concentration and fusion of nucleus, appearance of the small vacuoles both in the cell body and in the nucleus were observed. Even when plasmin was liberated upon marrow leucocytes not only in vitro bur also in culture, the decrease in number or any change of the leucocytes could not be observed. It was clarified that anti-plasmin could suppress the decrease of leucocytes by adding the active plasmin. In the case of anapylaxis of the rabbit sensitized with egg-albumin, the activation of plasmin and the decrease of the granular leucocytes were usually observed, expect a few cases.

Journal

Details 詳細情報について

Report a problem

Back to top