鼻アレルギー(病)の発症機序をめぐつて

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書誌事項

タイトル別名
  • Mechanism and Physiology of Nasal Allergy
  • 鼻アレルギー(病)の発症機序をめぐって
  • ハナ アレルギー ヤマイ ノ ハッショウ キジョ オ メグッテ

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抄録

The mechanism and physiology of nasal allergy were studied by means of techniques such as histochemistry, biochemistry, immunochemistry, autoradiography, vital microscopy and electronmicroscopy etc. The conclusions were as follows. 1. When allergic particle attached and deposited on the surface of the nasal mucous membrane, antigen was dissolved in the mucous blanket and penetrated into the epithelial layer. During the process reagenic or precipitate antibodies contained in the blanket were against the penetration of the antigen. 2. Immediately after antigen entered into the epithelial layer, antigen-antibody reaction occured possibly on the surface of the epithelial cells, being followed by the damage of the cells. The damage developed to manifestation of nasal symptoms such as sneezing, watery discharg and nasal obstruction. 3. There were many evidences, in which chemical mediator was not responsible for the first stage of the nasal allergic reaction in the epithelial layer. 4. The allergic reaction had to be appreciated as a defence mechanism against the penetration of foreign body into the mucous membrane. Sneezing reflex expelled an allergen from the surface of the membrane, and profuse watery secretion which came from the secretory gland and goblet cell washed out the surface. Nasal obstruction prevented any more penetration of the allergen into the nasal cavity. 5. Allergic reaction was influenced by the degree of the sensitization and sensitivity of the membrane. Local vagotonia caused an increase in the hydrogen ion concentration and decrease in the viscosity of the mucous blanket. Those accerelated the absorption rate of the antigen in the mucous membrane. 6. There were a local disturbance of the condition of the vasomotor nerve in vasomotor rhinitis which had nasal allergy like syptomes whithout negative skin test, although it was lesser than in nasal allergy. It was also shown that the occurrence of vasomotor rhinitis needed some other than vasomotor disturbance. 7. By specific hyposensitization with allergen extract improvement of symptome, decrease of watery discharge, eosinophilia, reaction in provocation and skin test with allergen were obtained in many caces of nasal allergy. In the improved cases there was an appearance of heamagglutination antibody in the blanket, using the bis-diazotized-benzidin technique, and decrease in the sensitivity of the epithel cell to offending allergen.

収録刊行物

  • アレルギー

    アレルギー 18 (8), 653-691,726, 1969

    一般社団法人 日本アレルギー学会

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