Significance of Serum Serotonin as the Chemical Mediator in Japanese Ceder Pollinosis

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  • Takamura Misao
    Department of Pharmacology and Oto-rhino-laryngo-pharyngology Nippon Medical School

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  • スギ花粉症患者の Chemical Mediator としての血中セロトニンの意義
  • スギ カフンショウ カンジャ ノ Chemical mediator ト シテ ノ ケッチュウ セロトニン ノ イギ

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Abstract

The measurement and significance of serum serotonin (5-HT) content in patients suffering from Japanese ceder pollinosis, were discussed. These patients were highly responsive to the clinical examinations for nasal allergy, i.e. skin test, provocation test of nasal mucous membrane and PK test. The nasal mucous membrane of patients was also highly sensitive to 5-HT applied locally. Morevoer, the 5-HT level in the serum of patients was found significantly higher in ceder-efflorescence season and after the provocation test of nasal mucous membrane with antigen (ceder-pollen-extract), than in non-efflorescence season and before the provocation test, respectively. In order to clarify the relationship between serum 5-HT level and nasal symptoms of patients, nialamide (50 mg/day), reserpine (4 mg/day) and cyproheptazine (12 mg/day) were orally administered. Serum 5-HT levels in the patients administered nialamide were found to be increasing and their nasal symptoms were aggravated. When cyproheptazine was administered, serum 5-HT level did not change and nasal symptoms improved. However in the cases administered reserpine, serum 5-HT level decreased, but nasal symptoms were aggravated. From the finding above mentioned, it might be said that the symptom of nasal allergy was not closely related to serum 5-HT content. Therefore, the measurement of serum 5-HT content in patients suffering from nasal allergy in general was not necessarily useful as the subsidary method in diagnosis.

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