気管支喘息に対するAurothioglucose(ロモゾール)の使用経験  [in Japanese] On the Treatment of Brochial Asthma with Aurothioglucose (Romosol)  [in Japanese]

Abstract

油性金製剤であるaurothioglucose (Romosol)をアメリカ方式で, 主として減感作療法の奏効しない症例に使用して次の成績がえられた.1)43例中著効16例, 有効15例, 無効5例, 不明7例で, 有効率86.1%であった.2)aurothioglucoseの治療効果は, ステロイド剤未使用群, 家族歴のある群, 若年群, アトピー型の群, 軽症群では, ステロイド剤長期使用群, 家族歴のない群, 高年群, 混合型ないし感染型の群, 重症群に比して有効率が高かった.3)有効例の大多数はaurothioglucoseの使用期間が3カ月以内に効果が発現している.無効例では5カ月以上治療を続けても効果がみられなかった.4)有効例ではaurothioglucoseの累積使用量が400mg以下で, 大多数の症例に効果の発現をみた.総使用量500mg以上やっても効果のあった症例は僅少であった.5)血中濃度と治療効果の間には一定の関係は認められなかった.6)aurothioglucoseによる治療を中止した後の2-3の症例に2-6カ月でreboundしたが, 再治療で軽快した.7)副作用としては, 〓痒を伴う発疹が最も多く, 次いで, 蛋白尿, 皮膚〓痒感, 口内炎で若い女性に多く現れる傾向がうかがわれ, 副作用発現時期と効果発現時期がほぼ一致する傾向がみられた.また, その発現時期は, 85-300mg, 特に85-150mg間に多かった.副作用の現れない人はいくら大量に使用しても平気であった.

Aurothioglucose (oil soluble) was mainly tested to the cases who did not show good effectiveness by American method in hyposensitization therapy, and the results obtained were as follows: 1) Among 43 patients treated with Aurothioglucose, the number of cases showed excellent result was 16, good 15, non-effective 5, unknown 7 and the total number of effective cases was31 (86.1%). 2) The effectiveness of the treatment was observed especially in the cases of patients who have not been treated with steroid therapy before, younger age, atopic type and mild cases. But the effectiveness was not so clear in patients who have been treated with steroid therapy for a long period, older age, mixed or infectious type and severe cases. 3) In most of the cases showed good results, the effectiveness was observed within 3 months after treatment, while in most of the non-effective cases the effectiveness could not be observed in the cases treated over 5 months. 4)In the cases with good results the effectiveness was observed with the administration of drugs within 400 mg as the total dosis. However, there are a few cases with good results who have the effectiveness was observed after the administration of over 500 mg. 5) Not a correlation was observed between the effectiveness and gold concentration in serum. 6) After treatment with Romosol, rebound was seen in 2-3 months, however, it was getting better with treatment. 7) As side effect exanthem with itching, albuminuria itching of skin and stomatitis were observed. Side effects were usually observed in young women, and the occurance of side effect and effectiveness of the drug were usually observed at the same period. The cases who did not show side effect were usually resistant to the administration of large amount of the drug.

Journal

Japanese Journal of Allergology   [List of Volumes]

Japanese Journal of Allergology 24(1), 1-5, 80, 1975-01-30  [Table of Contents]

The Japanese Society of Allergology

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Codes

  • NII Article ID (NAID) :
    110002409548
  • NII NACSIS-CAT ID (NCID) :
    AN00012583
  • Text Lang :
    JPN
  • ISSN :
    00214884
  • NDL Article ID :
    1581333
  • NDL Source Classification :
    SC321(呼吸器系)
  • NDL Source Classification :
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No. :
    Z19-32
  • Databases :
    NDL  NII-ELS 

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