On the Treatment of Brochial Asthma with Aurothioglucose (Romosol)

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  • Awazu Ryosuke
    The Second Department of Internal Medicine, National Matsuyama Hospital

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  • 気管支喘息に対するAurothioglucose(ロモゾール)の使用経験
  • キカンシ ゼンソク ニ タイスル Aurothioglucose ロモゾール

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Abstract

Aurothioglucose (oil soluble) was mainly tested to the cases who did not show good effectiveness by American method in hyposensitization therapy, and the results obtained were as follows: 1) Among 43 patients treated with Aurothioglucose, the number of cases showed excellent result was 16, good 15, non-effective 5, unknown 7 and the total number of effective cases was31 (86.1%). 2) The effectiveness of the treatment was observed especially in the cases of patients who have not been treated with steroid therapy before, younger age, atopic type and mild cases. But the effectiveness was not so clear in patients who have been treated with steroid therapy for a long period, older age, mixed or infectious type and severe cases. 3) In most of the cases showed good results, the effectiveness was observed within 3 months after treatment, while in most of the non-effective cases the effectiveness could not be observed in the cases treated over 5 months. 4)In the cases with good results the effectiveness was observed with the administration of drugs within 400 mg as the total dosis. However, there are a few cases with good results who have the effectiveness was observed after the administration of over 500 mg. 5) Not a correlation was observed between the effectiveness and gold concentration in serum. 6) After treatment with Romosol, rebound was seen in 2-3 months, however, it was getting better with treatment. 7) As side effect exanthem with itching, albuminuria itching of skin and stomatitis were observed. Side effects were usually observed in young women, and the occurance of side effect and effectiveness of the drug were usually observed at the same period. The cases who did not show side effect were usually resistant to the administration of large amount of the drug.

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