THE EFFECT OF THYROTROPIN RELEASING HORMONE ON THE PERIPHERAL AIRWAY RESPONSE INDUCED BY LEUKOTRIENE D

• Koshino Takeshi

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Fujimura Masaki

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Nishioka Shinji

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Okafuji Kazuhiro

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Minami Shinji

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Kanamori Kazunori

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Matsuda Tamotsu

  The Third Department of Medicine, School of Medicine, Kanazawa University

• Kitao Takeshi

  Kanazawa Wakamatsu Hospital

• Ishizaki Takeshi

  The Third Department of Medicine, Fukui Medical college

• Saga Tsutomu

  The Third Department of Medicine, Fukui Medical college

• Miyabo Susumu

  The Third Department of Medicine, Fukui Medical college

Bibliographic Information

Other Title

• Leukotriene D_4(LTD_4)吸入負荷時のThyrotropin Releasing Hormone(TRH)の末梢気道に及ぼす影響について

Abstract

The effect of thyrotropin releasing hormone (TRH) on bronchoconstriction in guinea pigs induced by leukotriene D_4 inhalation was investigated. Mean pulmonary resistance (R_L) and dynamic complaiance (C_<dyn>) were measured using a bodyplethysmograph for small animals and calculated by a microcomputor. 5 minutes following the leukotriene D_4 inhalation, C_<dyn> and R_L of the control group were -70.7±11.3% and +86.9±26.3%, those of the TRH(1mg/kg) pretreated group -60.2±11.1% and +78.8±27.8% and those of the TRH(2mg/kg) pretreated group -51.0±14.5%(p<0.05) and +81.6±27.7% respectively. However, administration of TRH(2mg/kg) 6 minutes after leukotriene D_4 inhalation exerted no influence on the effect of leukotriene D_4 on C_<dyn> and R_L. From these results, it is concluded that the sensitivity of the peripheral airway response to leukotriene D_4 was decreased by the pretreatment with TRH.

Journal

• Japanese Journal of Allergology

  Japanese Journal of Allergology 33 (12), 1059-1062, 1984

  Japanese Society of Allergology

Keywords

• dynamic compliance
• leukotriene D_4
• thyrotropin releasing hormone
• pulmonary resistance

Details

• CRID: 1390282679951414784
• NII Article ID: 110002414136
• DOI: 10.15036/arerugi.33.1059
• ISSN: 13477935
• ISSN: 00214884
• Web Site: https://search.jamas.or.jp/link/ui/1985191331
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed