気管支喘息の成分分析による臨床的解析の試み

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書誌事項

タイトル別名
  • Clinical Studies on Bronchial Asthma by Component Analysis
  • キカンシ ゼンソク ノ セイブン ブンセキ ニ ヨル リンショウテキ カイセキ ノ ココロミ

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抄録

The data of analysis were obtained from the results of 5 tests and 2 observations on 84 asthmatic patients in Tokyo University Hospital. The 5 tests were inhalative acetylcholine test, inhalative provocation test with house dust, intracutaneous test with house dust and the determination of FVC and % FEV_<1・0>/FVC. The 2 observations concerned severity and duration of asthma. In order to know the interrelation among the 5 tests and 2 observations, component analysis was carried out. The results were as follows: (1) "Individual points in test space" Representability of the individual variation of the 1st largest principal component was 41%, that of the 2nd was 17%, and that of the 3rd was 12%. Thus, these 3 largest principal components were able to explain about 70% of the individual variation. The 1st largest principal component was considered to relate to allergy, the 2nd to pulmonary function, and the 3rd to pulmonary hypersensitivity to chemical mediators. But, as a whole, an impression was obtained that the structure of factors in asthma was not constructed by a few leading components, rather it must be comprehended as a complex body composed of many relatively small components. (2) "Test vectors in individual space" In the 3 dimentional subspace embedded in 84 dimentional individual space, the 7 test vectors were able to explain about 70% of the individual variation. Three main axis were postulated in the subspace as follows: (1) allergic factor axis near the 1st largest principal component axis, (2) chemical mediator axis, and (3) pulmonary function axis. The presence of the latter 2 axis must be confirmed by more detailed experimental studies. Severity of asthma had positive correlation to inhalative provacation test, and duration of asthma had negative correlation the % FEV_<1・0>/FVC. It was the most interesting result of this analysis that allergic factor represented by 2 allergictests was considered to be significant to explain the individual differences of asthmatic patients and showed a relatively close relation to frequency and severity of asthmatic attacks. (3) The interrelation among 5 tests concerning the mechanism of asthmatic symptoms was found to be relatively stable regardless of the number of other tests. In these analyses, qualitative difference of factors concerning asthma was stressed and more attention was paid to the factors closely related to the mechnism of asthmatic symptoms.

収録刊行物

  • アレルギー

    アレルギー 14 (1), 13-19,41, 1965

    一般社団法人 日本アレルギー学会

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