抗体産生並びにアレルギー反応に及ぼす蛋白同化ステロイドの影響について

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タイトル別名
  • Experimental Studies on the Influences of Anabolic Steroids on the Production of Antibodies and Allergic Response
  • コウタイ サンセイ ナラビニ アレルギー ハンノウ ニ オヨボス タンパク ドウカ ステロイド ノ エイキョウ ニ ツイテ

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Influences of the anabolic sreroids on the production of antibodies and allergic responses in animals were studied and following results were obtained. 1. Rabbit were sensitized with egg-albumin and treated simultaneously with various anabolic steroids. (HMD, NTPP, Δ, 17MT and 4Cl-TA). Precipitating antibody titer and agglutination titer of the anti-egg-albumin serum was measured by the clinical test tube method and Boyden's method. Antibody titers in a group of rabbit which received anabolic ateroids were enhanced about 4-8 times compared with that in control group. It is likely that doses and method of treatment with anabolic steroids gave influences on production of antibodies in this experiment. 2. The rate of decrease in precipitating antibody titer after immunization was rather retarded in sera of rabbit treated with anabolic steroids compared with the rate in untreated rabbit. 3. Influence of anabolic steroids on anaphylactic shock induced in mice sensitized with horse serum. a) Minimum dose of antigen necessary to provoke active anaphylactic shock in mice showed no marked change by the use of anabolic steroids, but the mortality in the with anabolic steroids treated group was less than that of the untreated group. b) The degree of anaphylactic shock induced in mice had some connection with doses of anabolic steroids. c) In the induced anaphylactic shock in mice, mortality was increased in the group treated with both anabolic steroids and corticosteroid (Prednisolone). On the contrary, it decreased particularly in the group treated with HMD alone. d) Provocation of passive anaphylaxis in mice proved difficult. 4. Influence of anabolic steroids on anaphylactic shock induced in guinea pig. a) It was revealed that none of the anabolic steroids could inhibit or alleviate active anaphylactic shock. b) Concerning the passive anaphylactic shock induced in guinea pigs, the mortality rates in HMD treated group, with horse serum treated group, HMD and horse serum administered group, and in control group were 46%, 46%, 7.7% and 40% respectively. The score of symptoms of anaphylactic shock in group given both HMD and horse serum was extremely low. 5. Influence of anabolic steroids on passive cutaneous anaphylaxis^* induced in guinea pigs. (^*PCA) Following the original method by Ovary, PCA was induced in guinea pigs with an anti-horse rabbit serum. Anabolic steroids (HMD, Δ, 17MT, 4Cl-TA, and NTPP) and prednisolone were used in this experiment, and following results were obtained. a) The effects of anabolic steroids on PCA reaction proved beneficial. Similar effect of prednisolone was also observed. b) The PCA reaction in the group receiving anabolic steroids in combination with serum of other species differed from that in the control group, but the degree of inhibitory effect was similar in both anabolic steroids treated group and in with foreign protein treated group. 6. Influence of anabolic steroids and prednisoloneon the ratio; PCA antibody titer/precipitating antibody titer. Parallel with the production of precipitating antibody, production of the PCA antibody titer was increased, and the ratio of these antibodies was not different between the HMD treated group and control group. But the ratio in with prednisolone treated group was lower than that in other groups. 7. Influence of anabolic steroid alone on anti-hyaluronidase activity. The anti-hyaluronidase activity in rabbit was likely to increase by the anabolic steroids. Therefore, anabolic steroids as well as corticosteroid and ACTH seems to enhance the anti-hyaluronidase activity.

収録刊行物

  • アレルギー

    アレルギー 15 (8), 579-594,625-62, 1966

    一般社団法人 日本アレルギー学会

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