Plasmin に関する基礎的研究 : 第1編 各種測定法によるアナフィラキシーによる plasmin 活性値の変動 : 第2編 Trans 型 AMCHA の抗プラスミン作用と抗アナフィラキシー作用

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タイトル別名
  • Fundamental Studies on Plasmin : I. Change of plasmin activity by anaphylaxis-Determination by various methods- : II. Anti-plasmin and anti-anaphylactic action of Trans type AMCHA (Transamin)
  • Plasminに関する基礎的研究-1・2-
  • Plasmin ニ カンスル キソテキ ケンキュウ 1 2

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抄録

Changes of plasmin activity by anaphylaxis in guinea pigs were quantitatively determined by various method. As the plasmin materials serum-euglobulin isolated from serum was used. As the test euglobulin spontaneous euglobulin (SP-eug) and Streptokinase-activated euglobulin (SK-eug) were used. Deteminations of plasmin activity of SP-eug and SK-eug were comparatively studied by fibrin-plate method, fibrinogenolytic activity, fibrinolytic activity and caseinolytic activity. The increase of plasmin activity of SP-eug by anaphylaxis was observed in any kind of determination method and especially remarkable change was demonstrated by the methods of fibrinogenolysis and fibrinolysis. However not a remarkable change was observed between the plasmin activity in SK-eug obtained from pre and post anaphylactic shocks of guinea pigs. 2) Anti-plasmin activity of trans type AMCHA (transamin) and EACA (Ipsilon) was determinedby antifibrinolytic and anti-caseinolytic activity in vitro; and it was demonstrated that the former has several times more powerful action than the latter. 3. Protective effects of anti-plasmin drugs against anphylaxis in passively sensitized guinea pigs were tested and the anti-anaphylac action of transamin was also demonstrated in vivo. 4. Anti-plasmin drugs have no inhibiting actions against the isolated intestinal contraction of guinea pigs by histamine, acetylcholine or bradykinin and PCA-reaction in guinea pigs was only slightly ingibited by the pre-treatment of large amounts of anti-plasmin drugs (1 g/kg).

収録刊行物

  • アレルギー

    アレルギー 15 (9), 755-763,814, 1966

    一般社団法人 日本アレルギー学会

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