腎炎における血清補体価

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タイトル別名
  • Serum Complement Levels in Nephritis
  • ジンエン ニ オケル ケッセイホタイカ

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抄録

To determine serum complement levels in 79 patients with nephritis, C' and C'1, and immune adherence (I.A.) were estimated by the methods of Mayer's and Nelson-Nishioka's, respectively. During the first week after the onset of acute glomerulonephritis, both C' and I.A. were extremely low, C'1 being normal. As to the lowered C's, they mostly returned to normal in three weeks, while the depressed I.A. remained unchanged during the entire course of illness in most cases. In all the patients with acute glomerulonephritis which tended to heal or prolong, and chronic glomerulonephritis which was in latent, progressive or terminal stage, both C' and C'were normal, while I.A. showed low values. In patients with nephrotic syndrome, there was an extremely fluctuated serum complement level, with very low values in some cases. However, the cases, with improved proteinurias by steroid treatmentsin vitro and in vivo has no decreasing effects on C'. In the initial stage of subacute nephritis, C' remained low for prolonged periods of time. The C' of patients with chronic glomerulonephritis with frequent exacerbations was subnormal, but it temporarily became normal during and/or immediately after exacerbations. In patients with lupus nephritis, both C'and I.A. correlated well with their clinical states. Tonsillectomy was not followed by significant decrease in C', C'1 and I.A. values. Positive correlation between C'and I.A. found in this study suggests that the changes of C' result from that of I.A.

収録刊行物

  • アレルギー

    アレルギー 16 (4), 249-269,298-29, 1967

    一般社団法人 日本アレルギー学会

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