Study on Ciliary Activity of Respiratory Epithelium in Experimental Bronchial Asthma : Report 2.

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  • Aoki Mieko
    First Department of Internal Medicine, School of Medicine, Gunma University

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  • 気管支喘息における気道上皮の線毛運動に関する実験的研究 : 第2報
  • 気管支喘息における気道上皮の線毛運動に関する実験的研究
  • キカンシ ゼンソク ニ オケル キドウ ジョウヒ ノ センモウ ウンドウ ニ カンスル ジッケンテキ ケンキュウ

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Abstract

The author has already reported that the ciliary movement of the respiratory epithelium from the sensitized guinea pigs was specifically suppressed by the antigen in vitro. In order to know the ciliary activity during asthmatic attack, the author presented in this paper some experimental results in the guinea pig. Used antigen was"Maiko"which is the offending allergen of Konjac bronchial asthma in human beings, and is a dust from Amorphophalus Konjac K. Koch. The fragments of the ciliated epithelium of the guinea pig obtained by scratching the tracheal mucosa with the strate curett after the established inhalation. The frequency of ciliary movement was estimated by cinematographic recording under the phasedifference microscope. The frequency of ciliary movement was markedly decreased when the sensitized guinea pigs were exposed to"Maiko", whereas that of non-sensitized one was not influenced with"Maiko"inhalation. On the other hand, in acetylcholine-induced asthma, the frequency of ciliary movement was moderately decreased, but only slight decrease was observed in histamine-induced asthma. These results suggest that ciliary activity plays and important role in development of bronchial asthma, however, the allergic asthma seems to be different from drug-induced asthma.

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