Antidiabetogenic constituents from Salacia species(Chemical & Pharmacological study)

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In the course of our studies on antidiabetogenic compounds from natural medicines and medicinal foodstuffs, we found that the extracts from the roots and stems of Salacia reticulata, S. oblonga, and S. chinensis showed substantial inhibitory effects on increase in serum glucose levels in oral sucrose- and maltose-loaded rats and inhibitory effects on intestinal α-glucosidase. Through bioassay-guided separation using α-glucosidase inhibitory activities, we isolated α-glucosidase inhibitors named salacinol and kotalanol with unique chemical structures from the active fractions together with several known phenolic compounds, new sesquiterpenes (salasols A and B) and triterpenes (kotalagenin 16-acetate, salasones A-E, salaquinones A and B). Furthermore, S. reticulata and its phenolic constituents were found to exhibit pancreatic lipase inhibitory and anti-obese effects. This paper summarizes our recent studies including the synthetic and structure-activity relationships on antidiabetogenic principles of Salacia species. In addition, clinical studies and safety evaluations of the extracts from S. reticulata and S. oblonga are summarized.

収録刊行物

  • 和漢医薬学雑誌

    和漢医薬学雑誌 22(Supplement_1), 145-153, 2005

    和漢医薬学会

被引用文献:  6件中 1-6件 を表示

各種コード

  • NII論文ID(NAID)
    110002555185
  • NII書誌ID(NCID)
    AA12035198
  • 本文言語コード
    ENG
  • 資料種別
    雑誌論文
  • ISSN
    18801447
  • NDL 記事登録ID
    7488973
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-1563
  • データ提供元
    CJP引用  NDL  NII-ELS 
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