Long-Term Inhalation of Nitric Oxide for a Patient With Primary Pulmonary Hypertension

• KOH Eikan

  Department of Pediatrics, Kanazawa Medical University

• NIIMURA Junko

  Department of Pediatrics, Kanazawa Medical University

• NAKAMURA Tsuneyuki

  Department of Pediatrics, Kanazawa Medical University

• YAMAKAGE Hitoyoshi

  Department of Pediatrics, Kanazawa Medical University

• TAKAHASHI Hiroaki

  Department of Pediatrics, Kanazawa Medical University

抄録

Primary pulmonary hypertension is a disease with a high mortality rate and for which there is no saticfactory medical treatment. The safety of long-term inhalation of nitric oxide(NO)as a treatment is described. A 9-year-old girl inhaled NO for 32 weeks, accompanied with oral administration of beraprost sodium. Although NO did not improve her long-term prognosis, it eased the patient's dyspnea and increased her blood oxygenation. At doses of 20 ppm or more, attempts to withdraw from inhaled NO seemed to lead to an immediate elevation of the pulmonary artery pressure. This rebound phenomenon did not happen at doses under 5 ppm. This case study suggests that long-term inhalation of NO is safe and effective, but that pulmonary hypertension may rebound following withdrawal at higher doses of NO.

収録刊行物

• Japanese circulation journal

  Japanese circulation journal 62 (12), 940-942, 1998-11-20

  社団法人日本循環器学会

キーワード

• Inhaled nitric oxide
• Primary pulmonary hypertension
• Rebound phenomenon

詳細情報

• CRID: 1570009752290080896
• NII論文ID: 110002561139
• NII書誌ID: AA00690731
• ISSN: 00471828
• Web Site: https://search.jamas.or.jp/link/ui/1999129610
• 本文言語コード: en
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